Vitor Emanuel Cassol, Dirceu Solé, Sérgio Saldanha Menna-Barreto, Stefenia Pigatto Teche, Tiago Moraes Rizzato, Martin Maldonado, Diogo Ferrari Centenaro, Eliane Zenir Colpo Moraes

J Bras Pneumol.2005;31(3):191-196

Mortality due to pneumoconioses in macro regions of Brazil in the 1979-1998 period

Mortalidade por pneumoconioses nas macrorregiões do Brasil no período de 1979-1998

Hermano Albuquerque de Castro, Genésio Vicentin, Kellen Cristina Xavier Pereira

J Bras Pneumol.2003;29(2):82-88

Follow-up of patients diagnosed with and treated for tuberculosis in Brazil: financial burden on the household

Acompanhamento de pacientes com diagnóstico e tratamento de tuberculose no Brasil: ônus financeiro para a família

Rafaela Borge Loureiro ^1,2, Leticia Molino Guidoni ², Geisa Carlesso Fregona ^2,3, Sandra Maria do Valle Leone de Oliveira ^4,5, Daniel Sacramento ⁶, Jair dos Santos Pinheiro ^7,8, Denise Gomes ⁹, Ethel Leonor Noia Maciel ^1,2

J Bras Pneumol.2023;49(4):e20220368

Deaths attributed to multiple causes and involving tuberculosis in the state of Rio de Janeiro Brazil between 1999 and 2001

Causas múltiplas de morte relacionadas à tuberculose no Estado do Rio de Janeiro entre 1999 e 2001

Augusto Hasiak Santo

J Bras Pneumol.2006;32(6):544-552

Analysis of treatment outcomes related to the tuberculosis control program in the city of Campinas, in the state of São Paulo, Brazil

Análise do programa de controle da tuberculose em relação ao tratamento, em Campinas - SP

Helenice Bosco de Oliveira, Leticia Marin-León, Jovana Gardinali

J Bras Pneumol.2005;31(2):133-138

Background: Tuberculosis cure is dependent upon treatment adherence. Objective: To analyze the results of tuberculosis treatment in public health clinics in the city of Campinas, in the state of São Paulo, Brazil, during 2002. Method: From a cohort of 484 patients diagnosed with tuberculosis, we evaluated 436. Treatment outcomes were described for all patients, whether new patients or patients in retreatment, including those presenting the pulmonary form, with or without acquired immunodeficiency syndrome (AIDS) comorbidity. Results: The success rate was 68.6% (72.3% among non-AIDS patients and 57.6% among AIDS patients). Among new cases, the non-AIDS group presented a 2.2-times greater chance of presenting favorable results. In the AIDS group, no differences were observed between new patients and those in retreatment. Among the unfavorable outcomes, only lethality presented a difference (18.9% among AIDS patients and 8.0% among non-AIDS patients). In patients presenting the pulmonary form, the success rate was similar between those who were initially acid-fast bacilli positive and those who were not. Conclusion: The tuberculosis control program in Campinas presented low effectiveness. In comparison to the 2001 national cohort, success rates were higher for non-AIDS patients but lower for AIDS patients. The higher success rate among cases of tuberculosis without AIDS was primarily derived from the treatment of new cases. The unfavorable profile of tuberculosis patients co-infected with AIDS, characterized by the (18.9%) lethality and the (15.3%) noncompliance, were partially responsible for the lower success rate seen among such patients. It is notable that such high proportions of noncompliant patients were seen in a city providing easy access to treatment. In order to improve the program, medical teams should receive further training in supervised treatment, health education and techniques for interacting with patients, all of which will require considerable investment.

Keywords: Key words: Tuberculosis. Treatment Refusal. Retreatment. Acquired Immunodeficiency Syndrome. Comorbidity

Reasons for the admission, length of stay and type of discharge in tuberculosis hospitals in the State of São Paulo, Brazil - 1981 to 1995

Motivos e tempo de internação e o tipo de saída em hospitais de tuberculose do Estado de São Paulo, Brasil - 1981 a 1995

Péricles Alves Nogueira

J Bras Pneumol.2001;27(3):123-129

Evaluation of surveillance of contacts of new tuberculosis cases in the state of Mato Grosso - Brazil

Avaliação da vigilância de contatos de casos novos de tuberculose no Estado de Mato Grosso - Brasil

Shaiana Vilella Hartwig, Eliane Ignotti, Beatriz Fátima Alves de Oliveira, Hellen Caroline de Oliveira Pereira, João Henrique Scatena

J Bras Pneumol.2008;34(5):298-303

Continuing Education : Scientific Methodology

The Global Burden of Disease project: an online tool to compare disease impact across geographical regions over time

Rogelio Perez-Padilla1,2, Cecilia Maria Patino1,3, Juliana Carvalho Ferreira1,4

J Bras Pneumol.2024;50(6):e20240399

Original Article

Prevalence of temporary social security benefits due to respiratory disease in Brazil

Prevalência de benefícios de seguridade social temporários devido a doença respiratória no Brasil

Simone de Andrade Goulart Ildefonso, Anadergh Barbosa-Branco, Paulo Rogério Albuquerque-Oliveira

J Bras Pneumol.2009;35(1):44-53

Letters to the Editor

Adherence to long-term home oxygen therapy in patients with chronic respiratory disease in two cities in the state of Minas Gerais, Brazil

Adesão à oxigenoterapia domiciliar prolongada em pacientes com doença respiratória crônica em duas cidades do estado de Minas Gerais, Brasil

Felipe Meirelles de Azevedo1, Cristino Carneiro Oliveira1, Deborah Gollner Evangelista1, Leandro Ferracini Cabral1, Carla Malaguti1

J Bras Pneumol.2021;47(3):e20210055

Original Article

Drug resistance profile of Mycobacterium tuberculosis in the state of Mato Grosso do Sul, Brazil, 2000-2006

Perfil de resistência de Mycobacterium tuberculosis no estado de Mato Grosso do Sul, 2000-2006

Marli Marques, Eunice Atsuko Totumi Cunha, Antonio Ruffino-Netto, Sonia Maria de Oliveira Andrade

J Bras Pneumol.2010;36(2):224-231

Objective: To determine the drug resistance profile of Mycobacterium tuberculosis in the state of Mato Grosso do Sul, Brazil, between 2000 and 2006. Methods: Descriptive study of reported tuberculosis cases in the Brazilian Case Registry Database. We included only those cases in which M. tuberculosis culture was positive and sensitivity to drugs (rifampicin, isoniazid, streptomycin and ethambutol) was tested. Löwenstein-Jensen and Ogawa-Kudoh solid media were used for cultures, as was an automated liquid medium system. Sensitivity tests were based on the proportion method. Results: Among the 783 cases evaluated, males predominated (69.7%), as did patients in the 20-49 year age bracket (70%), a diagnosis of pulmonary tuberculosis (94.4%) and positive HIV serology (8.6%); 645 (82.4%) were new cases, and 138 (17.6%) had previously been treated. Resistance to at least one drug was found in 143 cases (18.3%). The primary resistance (PR) rate was, respectively, 8.1%, 1.6%, 2.8% and 12.4%, for monoresistance, multidrug resistance (MDR), other patterns of resistance and resistance to at least one drug, whereas the acquired resistance (AR) rate was 14.5%, 20.3%, 10.9% and 45.7%, respectively, and the combined resistance (CR) rate was 9.2%, 4.9%, 4.2% and 18.3%, respectively. In PR, streptomycin was the most common drug, whereas isoniazid was the most common in AR and CR (7.2% and 3.7%, respectively). Conclusions: These high levels of resistance undermine the efforts for tuberculosis control in Mato Grosso do Sul. Acquired MDR was 12.7 times more common than was primary MDR, demonstrating that the previous use of drug therapy is an indicator of resistance. These levels reflect the poor quality of the health care provided to these patients, showing the importance of using the directly observed treatment, short course strategy, as well as the need to perform cultures and sensitivity tests for the early diagnosis of drug resistance.

Keywords: Tuberculosis; Drug resistance, multiple; Mycobacterium tuberculosis.

Epidemiological aspects of pleural tuberculosis in the state of São Paulo, Brazil (1998-2005)

Aspectos epidemiológicos da tuberculose pleural no estado de São Paulo (1998-2005)

Márcia Seiscento, Francisco Suso Vargas, Maria Josefa Penon Rujula, Sidney Bombarda, David Everson Uip, Vera Maria Nedes Galesi

J Bras Pneumol.2009;35(6):548-554

Factors associated with delayed diagnosis of pulmonary tuberculosis in the state of Rio de Janeiro, Brazil

Fatores associados ao atraso no diagnóstico da tuberculose pulmonar no estado do Rio de Janeiro

Audry Cristina de Fátima Teixeira Machado, Ricardo Ewbank Steffen, Olivia Oxlade, Dick Menzies, Afrânio Kritski, Anete Trajman

J Bras Pneumol.2011;37(4):512-520

Characteristics of tuberculosis in the state of Minas Gerais, Brazil: 2002-2009

Características da tuberculose no estado de Minas Gerais entre 2002 e 2009

Cláudio José Augusto, Wânia da Silva Carvalho, Alan Douglas Gonçalves, Maria das Graças Braga Ceccato, Silvana Spindola de Miranda

J Bras Pneumol.2013;39(3):357-364

Objective: To analyze the profile of tuberculosis cases reported between 2002 and 2009 in the state of Minas Gerais, Brazil, according to sociodemographic, clinical, and laboratory characteristics, as well as to comorbidities and mortality. Methods: This was a descriptive, epidemiological study based on data obtained from the Brazilian Case Registry Database and the Brazilian Mortality Database for the 2002-2009 period. Results: There were 47,285 reported cases of tuberculosis, corresponding to a mean incidence of 22.3/100,000 population. The individuals diagnosed with tuberculosis were predominantly in the 20- to 49-year age bracket and male (62.4% and 67.0%, respectively). Individuals with a low level of education accounted for 18.5% of the cases. New cases, cases of recurrence, and cases of retreatment accounted for 83.7%, 5.7%, 5.7%, respectively. The rates of cure and treatment noncompliance were 66.2% and 11.2%, respectively; multidrug-resistant tuberculosis was identified in 0.2% of the cases; and the mortality rate was 12.9%. The directly observed treatment, short-course (DOTS) strategy was applied in 21.8% of the cases. Sputum smear microscopy and culture were performed in only 73.9% and 12.9% of the cases, respectively. Chest X-rays were performed in 90.5% of the cases. Pulmonary tuberculosis was the predominant form (in 83.9%). Comorbidity with alcoholism, HIV infection, and diabetes mellitus were identified in 17.2%, 8.3%, and 3.8%, respectively. Conclusions: During the study period, the numbers of new cases, cases of treatment noncompliance, and deaths were high, comorbidities were common, and there was a failure to perform adequately basic tests for the diagnosis of tuberculosis. Multidisciplinary approaches, expanded use of the DOTS strategy, better knowledge of the distribution of tuberculosis, and improvements in the databases are needed in order to achieve better control of the disease in the state of Minas Gerais.

Keywords: Tuberculosis/epidemiology; Tuberculosis/mortality; Information systems.

Pleural tuberculosis in the state of Roraima, Brazil, between 2005 and 2013: quality of diagnosis

Tuberculose pleural no estado de Roraima no período de 2005-2013: qualidade diagnóstica

Tao Machado1, Allex Jardim da Fonseca2, Sandra Maria Franco Buenafuente2

J Bras Pneumol.2016;42(2):106-113

Brief Communication

Tuberculosis and gender in a priority city in the state of Rio de Janeiro, Brazil

Tuberculose e gênero em um município prioritário no estado do Rio de Janeiro

Márcia Teresa Carreira Teixeira Belo, Ronir Ragio Luiz, Christy Hanson, Lia Selig, Eleny Guimarães Teixeira, Thiago Chalfoun, Anete Trajman

J Bras Pneumol.2010;36(5):621-625

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