Original Article

Diffuse aspiration bronchiolitis: analysis of 20 consecutive patients

Bronquiolite aspirativa difusa: análise de 20 pacientes consecutivos

J Bras Pneumol.2015;41(2):161-166

Correlation between the severity of critically ill patients and clinical predictors of bronchial aspiration

Correlação entre a gravidade de pacientes críticos e preditores clínicos de risco para a broncoaspiração

Gisele Chagas de Medeiros1, Fernanda Chiarion Sassi2, Lucas Santos Zambom3, Claudia Regina Furquim de Andrade2

J Bras Pneumol.2016;42(2):114-120

Lung abscess: analysis of 252 consecutive cases diagnosed between 1968 and 2004

Abscesso pulmonar de aspiração: análise de 252 casos consecutivos estudados de 1968 a 2004

José da Silva Moreira, José de Jesus Peixoto Camargo, José Carlos Felicetti, Paulo Roberto Goldenfun, Ana Luiza Schneider Moreira, Nelson da Silva Porto

J Bras Pneumol.2006;32(2):136-143

Validation of the Airways questionnaire 20 - AQ20 in patients with chronic obstructive pulmonary disease (COPD) in Brazil

Validação do questionário de vias aéreas 20 ("Airways questionnaire 20" - AQ20) em pacientes portadores de doença pulmonar obstrutiva crônica (DPOC) no Brasil

Aquiles Camelier, Fernanda Rosa, Paul Jones, José Roberto Jardim

J Bras Pneumol.2003;29(1):28-35

Continuing Education: Imaging

Diffuse opacification of the hemithorax

Velamento difuso do hemitórax

Edson Marchiori1, Bruno Hochhegger2, Gláucia Zanetti1

J Bras Pneumol.2022;48(5):e20220382

Letters to the Editor

Brazilian Tuberculosis Research Network: 20 years of history in the fight against Tuberculosis

Rede Brasileira de Pesquisa em Tuberculose: 20 anos de história na luta contra a Tuberculose

Ethel L. Maciel1, Ricardo A. Arcêncio1, José R. Lapa e Silva1

J Bras Pneumol.2021;47(6):e20210341

Original Article

Evaluating bronchodilator response in pediatric patients with post-infectious bronchiolitis obliterans: use of different criteria for identifying airway reversibility

Avaliação da resposta ao broncodilatador em pacientes pediátricos com bronquiolite obliterante pós-infecciosa: uso de diferentes critérios de identificação de reversibilidade das vias aéreas

Rita Mattiello1, Paula Cristina Vidal2, Edgar Enrique Sarria3, Paulo Márcio Pitrez1, Renato Tetelbom Stein1, Helena Teresinha Mocelin4, Gilberto Bueno Fischer4, Marcus Herbert Jones1, Leonardo Araújo Pinto1

J Bras Pneumol.2016;42(3):174-178

Analysis of dry pleural biopsy in 107 patients

Análise da biópsia pleural em 107 pacientes sem líquido pleural

Marcelo Chalhoub, Sérgio Arruda, Ronald Fidélis, Ana Paula Barreto, Manoel Barral Netto

J Bras Pneumol.1999;25(3):141-146

The clinical-radiographic presentation and tuberculosis prediction in patients that have undergone dry pleural biopsy, as well as its usefulness and complications, have been evaluated in this retrospective study, conducted in the Octávio Mangabeira Hospital (Salvador, Bahia, Brazil), where 107 patients consecutively submitted to this exam have been analyzed. Altogether 108 biopsies have been performed using Cope's needle (biopsies of both hemithoraxes were performed in one patient). The following diagnoses were obtained: a) tuberculosis (n = 66); b) probable tuberculosis (n = 4); c) neoplasm (n = 2); d) parapneumonic (n = 3), and e) not determined (32). Sixty-seven (62.6%) of the patients were male, and mean age was 34.5 ± 15.4 years. Analyses carried out compare patients diagnosed with tuberculosis (whether confirmed or probable) to those with different diagnoses (miscellaneous). Tuberculosis patients were younger (p < 0.01), expectoration was less frequent (p < 0.01), previous tuberculosis was less often reported (p = 0.04) and PPD reactivity was more frequent (p < 0.01). No significant differences were found between the two groups as to the extent of pleural commitment and its variation in the period observed. Presence of acinar infiltrations in the upper lobes was correlated with tuberculosis diagnosis in the 13 patients in which this feature was observed. Pleural fragments were present in 100 out of 108 cases (92.6%) and the diagnosis was made in the first biopsy in 64 out of 108 cases (59.3%). Ten minor complications have occurred (9.3%) in the 108 biopsies: 6 bloody sputums, 3 small pneumothoraxes, and one moderate subcutaneous emphysema. The authors conclude that for the various predictive indicators of tuberculosis analyzed, except for the presence of acinar infiltrations in the upper lobes, there is broad overlap between the two groups compared, meaning that a safe clinical diagnosis cannot be provided and thus reinforcing the need of performing biopsies. Dry pleural biopsy offers a satisfactory diagnostic yield in areas with high prevalence of tuberculosis and proved safe, when performed by experienced personnel.

Keywords: Pleural tuberculosis. Pleural thickening. Pleural biopsy. Diagnosis.

Hospitalized patients with COPD: analysis of prior treatment

Pacientes portadores de DPOC hospitalizados: análise do tratamento prévio

Irai Luis Giacomelli, Leila John Marques Steidle, Frederico Fernandes Moreira, Igor Varela Meyer, Ricardo Goetten Souza, Mariângela Pimentel Pincelli

J Bras Pneumol.2014;40(3):229-237

Objective: Although COPD is a prevalent disease, it is undertreated, and there are no available data regarding previous treatment of COPD in Brazil. This study aimed to determine the appropriateness of maintenance treatment in COPD patients prior to their hospitalization and to identify variables associated with inappropriate treatment. Methods: This was an observational, cross-sectional, analytical study involving 50 inpatients with COPD at two hospitals in the city of Florianópolis, Brazil. The patients completed a questionnaire on parameters related to the maintenance treatment of COPD. Non-pharmacological management and pharmacological treatment were assessed based on the recommendations made by the Global Initiative for Chronic Obstructive Lung Disease (GOLD) in 2011 and by the Brazilian National Ministry of Health in the chronic respiratory diseases section of its Caderno de Atenção Básica (CAB, Primary Care Guidebook). Results: In most of the patients, the COPD was classified as being severe or very severe. Regarding non-pharmacological management, 33% of the patients were smokers, only 32% had been advised to receive the flu vaccine, 28% had received pneumococcal vaccine, and only 6.5% of the patients in the B, C, and D categories received pulmonary rehabilitation. Regarding GOLD and CAB recommendations, pharmacological treatment was inappropriate in 50% and 74% of the patients, respectively. Based on GOLD recommendations, 38% were undertreated. A low level of education, low income, not receiving oxygen therapy, and not receiving the flu vaccine were associated with inappropriate treatment. Conclusions: The application of various non-pharmacological management recommendations was unsatisfactory. Regarding the GOLD recommendations, the high rate of inappropriate maintenance treatment was mainly due to undertreatment. In Brazil, even in severe COPD cases, optimizing treatment to achieve greater benefits continues to be a challenge.

Keywords: Pulmonary disease, chronic obstructive/therapy; Pulmonary disease, chronic obstructive/prevention and control; Clinical protocols.

The role of endobronchial ultrasound-guided transbronchial needle aspiration in isolated intrathoracic lymphadenopathy in non-neoplastic patients: a common dilemma in clinical practice

O papel da aspiração transbrônquica com agulha guiada por ultrassonografia endobrônquica na linfonodomegalia intratorácica isolada em pacientes não neoplásicos: um dilema comum na prática clínica

Lília Maia Santos1,2, Viviane Rossi Figueiredo3, Sergio Eduardo Demarzo3, Addy Lidvina Mejia Palomino3, Márcia Jacomelli3

J Bras Pneumol.2020;46(2):e20180183

Objective: To determine the diagnostic yield of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in non-neoplastic patients with isolated intrathoracic lymphadenopathy (IL). Methods: This was a retrospective study of patients with isolated IL referred for EBUS-TBNA. We calculated the sensitivity, specificity, accuracy, positive predictive value (PPV), and negative predictive value (NPV) of EBUS-TBNA in the diagnosis of granulomatous, reactive, and neoplastic lymphadenopathy. In cases of nonspecific granulomas, reactive lymphadenopathy, or inconclusive results, a definitive diagnosis was established by other diagnostic procedures or during a follow-up period of at least 18 months. Results: Among the 58 patients included in the study, EBUS-TBNA established a diagnosis of granulomatous disease in 22 (38%), reactive lymphadenopathy in 15 (26%), cancer in 8 (14%), and other diseases in 3 (5%). Results were inconclusive in 10 (17%), the diagnosis being established by other bronchoscopic procedures in 2 (20%) and by surgical procedures in 8 (80%). A final diagnosis of reactive lymphadenopathy was established in 12. Of those, 11 (92%) had their diagnosis confirmed during follow-up and 1 (8%) had their diagnosis confirmed by mediastinoscopy. In another 3, a final diagnosis of sarcoidosis or neoplasm was established. For the diagnosis of granulomatous disease, neoplasms, and reactive lymphadenopathy, EBUS-TBNA was found to have a sensitivity of 73%, 68%, and 92%, respectively; a specificity of 100%, 100%, and 93%, respectively; an accuracy of 86%, 93%, and 93%, respectively; a PPV of 100%, 100%, and 80%, respectively; and an NPV of 78%, 92%, and 98%, respectively. Conclusions: In non-neoplastic patients, granulomatous disease and reactive lymphadenopathy appear to be common causes of isolated IL. EBUS-TBNA shows promising results as a first-line minimally invasive diagnostic procedure. The results obtained by EBUS-TBNA can be optimized by examining clinical and radiological findings during follow-up or by comparison with the results obtained with other bronchoscopic methods.

Keywords: Endoscopic ultrasound-guided fine needle aspiration; Lymphadenopathy/diagnosis; Neoplasms.

Letters to the Editor

Tiotropium use and pulmonary function in patients with constrictive bronchiolitis

Uso de tiotrópio e função pulmonar em portadores de bronquiolite constritiva

Alexandre Melo Kawassaki, Letícia Kawano-Dourado, Ronaldo Adib Kairalla

J Bras Pneumol.2014;40(1):86-88

Pictorial Essay

Diffuse abnormalities of the trachea: computed tomography findings

Alterações difusas da traquéia: aspectos na tomografia computadorizada

Edson Marchiori, Aline Serfaty Pozes, Arthur Soares Souza Junior, Dante Luiz Escuissato, Klaus Loureiro Irion, César de Araujo Neto, Jorge Luiz Barillo, Carolina Althoff Souza, Gláucia Zanetti

J Bras Pneumol.2008;34(1):47-54

Original Article

Video-assisted thoracoscopy for the diagnosis of diffuse parenchymal lung disease

A videotoracoscopia no diagnóstico das doenças difusas do parênquima pulmonar

Renato Tadao Ishie, João José de Deus Cardoso, Rafael José Silveira, Lucas Stocco

J Bras Pneumol.2009;35(3):234-241

Editorial

Diffuse lung diseases and HRCT: limitations of radiologists

Doenças pulmonares difusas e TCAR: os limites do radiologista

Dante Luiz Escuissato

J Bras Pneumol.2010;36(1):6-7

Continuing Education: Imaging

Diffuse thickening of the tracheal wall, with calcifications

Espessamento difuso da parede traqueal, com calcificações

Edson Marchiori1, Bruno Hochhegger2, Gláucia Zanetti1

J Bras Pneumol.2022;48(4):e20220223

Continuing Education: Pediatric Pulmonology

Management of bronchiolitis and recurrent wheezing in preschoolers

Manejo da bronquiolite e da sibilância recorrente em pré-escolares

Eduardo da Costa Herter1, Luiza Fernandes Xavier1, Paula Barros de Barros1, Sofia Prates da Cunha de Azevedo1, Magali Santos Lumertz1,2, Leonardo Araujo Pinto1,2

J Bras Pneumol.2023;49(5):e20230298

Review Article

Chest CT findings in patients with dysphagia and aspiration: a systematic review

Achados de TC de tórax em pacientes com disfagia e aspiração pulmonar: uma revisão sistemática

Betina Scheeren1, Erissandra Gomes2, Giordano Alves3, Edson Marchiori3, Bruno Hochhegger1

J Bras Pneumol.2017;43(4):313-318

Original Article

Analysis of three different equations for predicting quadriceps femoris muscle strength in patients with COPD

Análise de três diferentes fórmulas de predição de força muscular do quadríceps femoral em pacientes com DPOC

Aline Gonçalves Nellessen¹, Leila Donária¹, Nidia Aparecida Hernandes¹, Fabio Pitta¹

J Bras Pneumol.2015;41(4):305-312

Systematic Reviews and Meta-analyses

Use of remdesivir in patients with COVID-19: a systematic review and meta-analysis

Uso de remdesivir em pacientes com COVID-19: revisão sistemática e meta-análise

Suzana E Tanni1, Antonio Silvinato2, Idevaldo Floriano3, Hélio A Bacha4, Alexandre Naime Barbosa5, Wanderley M Bernardo6

J Bras Pneumol.2022;48(1):e20210393

Original Article

Validation of a bioelectrical impedance analysis system for body composition assessment in patients with COPD

Validação de um sistema de análise de impedância bioelétrica para a avaliação da composição corporal de pacientes com DPOC

Fernanda Rodrigues Fonseca1,2,a, Manuela Karloh2,3,b, Cintia Laura Pereira de Araujo1,2,c, Cardine Martins dos Reis1,2,d, Anamaria Fleig Mayer1,2,3,e

J Bras Pneumol.2018;44(4):315-320

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