Diego de Faria Magalhães Torres1, Aléxia Carolina Soares do Nascimento2, Sara Ferreira Destro3, Alexandre Pinto Cardoso4, Fernanda Carvalho de Queiroz Mello4

J Bras Pneumol.2021;47(4):e20210170

Original Article

Assessment of the quality of life of patients with lung cancer using the Medical Outcomes Study 36-item Short-Form Health Survey

Avaliação da qualidade de vida em pacientes com câncer de pulmão através da aplicação do questionário Medical Outcomes Study 36-item Short-Form Health Survey

Juliana Franceschini, Alecssandra Aparecida dos Santos, Inás El Mouallem, Sergio Jamnik, César Uehara, Ana Luisa Godoy Fernandes, Ilka Lopes Santoro

J Bras Pneumol.2008;34(6):387-393

Immunohistochemical and morphometric evaluation of COX‑1 and COX-2 in the remodeled lung in idiopathic pulmonary fibrosis and systemic sclerosis

Avaliação imuno-histoquímica e morfométrica de COX-1 e COX-2 no remodelamento pulmonar na fibrose pulmonar idiopática e na esclerose sistêmica

J Bras Pneumol.2013;39(6):692-700

Case Report

Diffuse systemic sclerosis with isolated pulmonary hypertension: a case report

Esclerose sistêmica difusa com hipertensão pulmonar isolada: relato de caso

Silméia Garcia Zanati, Katashi Okoshi, Luiz Shiguero Matsubara, Roberto Minoru Tani Inoue, Marina Politi Okoshi

J Bras Pneumol.2000;26(6):313-316

Original Article

Applicability of the London Chest Activity of Daily Living scale in patients on the waiting list for lung transplantation

Aplicabilidade da escala London Chest Activity of Daily Living em pacientes em lista de espera para transplante de pulmão

Jocimar Prates Muller, Patrícia Ayres Guterres Gonçalves, Fabrício Farias da Fontoura, Rita Mattiello, Juliessa Florian

J Bras Pneumol.2013;39(1):92-97

PET/CT and inflammatory mediators in systemic sclerosis-associated interstitial lung disease

PET/TC e mediadores inflamatórios na doença pulmonar intersticial associada à esclerose sistêmica

Andréa L Bastos1, Gilda A Ferreira2, Marcelo Mamede1, Eliane V Mancuzo3, Mauro M Teixeira4, Flávia P S T Santos5, Cid S Ferreira6, Ricardo A Correa3

J Bras Pneumol.2022;48(4):e20210329

Objective: To investigate the correlation of HRCT findings with pulmonary metabolic activity in the corresponding regions using 18F-FDG PET/CT and inflammatory markers in patients with systemic sclerosis (SSc)-associated interstitial lung disease (ILD). Methods: This was a cross-sectional study involving 23 adult patients with SSc-associated ILD without other connective tissue diseases. The study also involved 18F-FDG PET/CT, HRCT, determination of serum chemokine levels, clinical data, and pulmonary function testing. Results: In this cohort of patients with long-term disease (disease duration, 11.8 ± 8.7 years), a nonspecific interstitial pneumonia pattern was found in 19 (82.6%). Honeycombing areas had higher median standardized uptake values (1.95; p = 0.85). Serum levels of soluble tumor necrosis factor receptor 1, soluble tumor necrosis factor receptor 2, C-C motif chemokine ligand 2 (CCL2), and C-X-C motif chemokine ligand 10 were higher in SSc patients than in controls. Serum levels of CCL2-a marker of fibroblast activity-were correlated with pure ground-glass opacity (GGO) areas on HRCT scans (p = 0.007). 18F-FDG PET/CT showed significant metabolic activity for all HRCT patterns. The correlation between serum CCL2 levels and GGO on HRCT scans suggests a central role of fibroblasts in these areas, adding new information towards the understanding of the mechanisms surrounding cellular and molecular elements and their expression on HRCT scans in patients with SSc-associated ILD. Conclusions: 18F-FDG PET/CT appears to be unable to differentiate the intensity of metabolic activity across HRCT patterns in chronic SSc patients. The association between CCL2 and GGO might be related to fibroblast activity in these areas; however, upregulated CCL2 expression in the lung tissue of SSc patients should be investigated in order to gain a better understanding of this association.

Keywords: Tomography; Lung diseases, interstitial; Scleroderma, systemic; Cytokines.

Systemic effects of nocturnal hypoxemia in patients with chronic obstructive pulmonary disease without obstructive sleep apnea syndrome

Efeitos sistêmicos da hipoxemia noturna em pacientes com doença pulmonar obstrutiva crônica sem síndrome da apnéia obstrutiva do sono

Paulo de Tarso Guerrero Mueller, Marcílio Delmondes Gomes, Carlos Alberto de Assis Viegas, José Alberto Neder

J Bras Pneumol.2008;34(8):567-574

Case Report

Use of volume-targeted non-invasive bilevel positive airway pressure ventilation in a patient with amyotrophic lateral sclerosis

Utilização de ventilação não invasiva com dois níveis de pressão positiva nas vias aéreas e volume alvo em paciente com esclerose lateral amiotrófica

Montserrat Diaz-Abad, John Edward Brown

J Bras Pneumol.2014;40(4):443-447

Original Article

Cardiorespiratory response to incremental progressive maximal exercise in asthmatic patients

Resposta cardiorrespiratória na asma induzida pelo exercício máximo com incrementos progressivos

Ruy Amazonas Lamar Filho, Antonio Augusto Soares da Fonseca, Maria Alice Melo Neves, Laércio Moreira Valença

J Bras Pneumol.2001;27(3):137-142

Random sample survey on the prevalence of smoking in the major cities of Brazil

Levantamento randomizado sobre a prevalência de tabagismo nos maiores municípios do Brasil

Fernando Sergio Leitão Filho, José Carlos Fernandes Galduróz, Ana Regina Noto, Solange Aparecida Nappo, Elisaldo Araújo Carlini, Oliver Augusto Nascimento, Sérgio Ricardo Santos, José Roberto Jardim

J Bras Pneumol.2009;35(12):