Case Report

Shrinking lung syndrome in systemic lupus erythematosus

Síndrome do pulmão encolhido no lúpus eritematoso sistêmico

Cíntia Andrade Costa, Dálvaro Oliveira de Castro Jr., Sérgio Jezler, Mettermayer Santiago

J Bras Pneumol.2004;30(3):260-263

Sildenafil for treatment of pulmonary hypertension in association with systemic lupus erythematosus and anti-phospholipid syndrome

Sildenafil no tratamento da hipertensão pulmonar associada a lúpus eritematoso sistêmico e síndrome antifosfolipídio

Eduardo José do Rosário e Souza, Junia Rios Garib, Nasim Michel Garib, Paulo Madureira de Pádua

J Bras Pneumol.2003;29(5):302-304

Silicosis associated with systemic lupus erythematosus

Associação de silicose e lúpus eritematoso sistêmico

Shirley Castro Holanda, Maria do Socorro T.M. Almeida, Antônio de Deus Filho

J Bras Pneumol.2003;29(4):221-224

Systemic corticosteroids as first-line treatment in pulmonary hypertension associated with POEMS syndrome

Corticoide sistêmico como tratamento de primeira linha da hipertensão pulmonar secundária a síndrome POEMS

Samia Rached, Rodrigo Abensur Athanazio, Sérvulo Azevedo Dias Júnior, Carlos Jardim, Rogério Souza

J Bras Pneumol.2009;35(8):804-808

Original Article

Systemic effects of nocturnal hypoxemia in patients with chronic obstructive pulmonary disease without obstructive sleep apnea syndrome

Efeitos sistêmicos da hipoxemia noturna em pacientes com doença pulmonar obstrutiva crônica sem síndrome da apnéia obstrutiva do sono

Paulo de Tarso Guerrero Mueller, Marcílio Delmondes Gomes, Carlos Alberto de Assis Viegas, José Alberto Neder

J Bras Pneumol.2008;34(8):567-574

Interstitial lung disease in patients with progressive systemic sclerosis. A study of 58 cases

Comprometimento do interstício pulmonar em portadores de esclerose sistêmica progressiva. Estudo de uma série de 58 casos

Sergio Fernandes de Oliveira Jezler, Mittermayer Barreto Santiago, Thamine Lessa Andrade, César Araujo Neto, Helio Braga, Álvaro Augusto Cruz

J Bras Pneumol.2005;31(4):300-306

PET/CT and inflammatory mediators in systemic sclerosis-associated interstitial lung disease

PET/TC e mediadores inflamatórios na doença pulmonar intersticial associada à esclerose sistêmica

Andréa L Bastos1, Gilda A Ferreira2, Marcelo Mamede1, Eliane V Mancuzo3, Mauro M Teixeira4, Flávia P S T Santos5, Cid S Ferreira6, Ricardo A Correa3

J Bras Pneumol.2022;48(4):e20210329

Objective: To investigate the correlation of HRCT findings with pulmonary metabolic activity in the corresponding regions using 18F-FDG PET/CT and inflammatory markers in patients with systemic sclerosis (SSc)-associated interstitial lung disease (ILD). Methods: This was a cross-sectional study involving 23 adult patients with SSc-associated ILD without other connective tissue diseases. The study also involved 18F-FDG PET/CT, HRCT, determination of serum chemokine levels, clinical data, and pulmonary function testing. Results: In this cohort of patients with long-term disease (disease duration, 11.8 ± 8.7 years), a nonspecific interstitial pneumonia pattern was found in 19 (82.6%). Honeycombing areas had higher median standardized uptake values (1.95; p = 0.85). Serum levels of soluble tumor necrosis factor receptor 1, soluble tumor necrosis factor receptor 2, C-C motif chemokine ligand 2 (CCL2), and C-X-C motif chemokine ligand 10 were higher in SSc patients than in controls. Serum levels of CCL2-a marker of fibroblast activity-were correlated with pure ground-glass opacity (GGO) areas on HRCT scans (p = 0.007). 18F-FDG PET/CT showed significant metabolic activity for all HRCT patterns. The correlation between serum CCL2 levels and GGO on HRCT scans suggests a central role of fibroblasts in these areas, adding new information towards the understanding of the mechanisms surrounding cellular and molecular elements and their expression on HRCT scans in patients with SSc-associated ILD. Conclusions: 18F-FDG PET/CT appears to be unable to differentiate the intensity of metabolic activity across HRCT patterns in chronic SSc patients. The association between CCL2 and GGO might be related to fibroblast activity in these areas; however, upregulated CCL2 expression in the lung tissue of SSc patients should be investigated in order to gain a better understanding of this association.

Keywords: Tomography; Lung diseases, interstitial; Scleroderma, systemic; Cytokines.

Continuing Education: Imaging

Anomalous systemic arterial supply to normal lung

Edson Marchiori1, Bruno Hochhegger2, Gláucia Zanetti1

J Bras Pneumol.2024;50(2):e20240034

Original Article

Immunohistochemical and morphometric evaluation of COX‑1 and COX-2 in the remodeled lung in idiopathic pulmonary fibrosis and systemic sclerosis

Avaliação imuno-histoquímica e morfométrica de COX-1 e COX-2 no remodelamento pulmonar na fibrose pulmonar idiopática e na esclerose sistêmica

J Bras Pneumol.2013;39(6):692-700

Review Article

Lung tissue remodeling in the acute respiratory distress syndrome

Remodelamento do tecido pulmonar na síndrome do desconforto respiratório agudo

Alba Barros de Souza, Flavia Brandão dos Santos, Elnara Marcia Negri, Walter Araujo Zin, Patricia Rieken Macedo Rocco

J Bras Pneumol.2003;29(4):235-245

Original Article

Lung function in post-poliomyelitis syndrome: a cross-sectional study

Função pulmonar em pessoas com síndrome pós-poliomielite: um estudo transversal

Claudio Andre Barbosa de Lira, Fábio Carderelli Minozzo, Bolivar Saldanha Sousa, Rodrigo Luiz Vancini, Marília dos Santos Andrade, Abrahão Augusto Juviniano Quadros, Acary Souza Bulle Oliveira, Antonio Carlos da Silva

J Bras Pneumol.2013;39(4):

Review Article

Systemic manifestations in chronic obstructive pulmonary disease

Manifestações sistêmicas na doença pulmonar obstrutiva crônica

Victor Zuniga Dourado, Suzana Erico Tanni, Simone Alves Vale, Márcia Maria Faganello, Fernanda Figueirôa Sanches, Irma Godoy

J Bras Pneumol.2006;32(2):161-171

Editorial

Is systemic sclerosis interstitial lung disease slowly progressive?

A doença pulmonar intersticial na esclerose sistêmica é lentamente progressiva?

Chitra Lal, Charlie Strange

J Bras Pneumol.2011;37(2):142-143

Letter to the Reader

Lung transplantation without the use of cardiopulmonary bypass in a patient with Kartagener syndrome

Transplante pulmonar sem circulação extracorpórea em uma paciente com síndrome de Kartagener

Luziélio Alves Sidney Filho, Tiago Noguchi Machuca, José de Jesus Camargo, José Carlos Felicetti, Spencer Marcantonio Camargo, Fabíola Adélia Perin, Letícia Beatriz Sanchez, Sadi Marcelo Schio

J Bras Pneumol.2012;38(6):806-809

Review Article

Acquired immunodeficiency syndrome and the lung

A síndrome da imunodeficiência adquirida e o pulmão

Rosemeri Maurici da Silva

J Bras Pneumol.2000;26(1):44-48

Original Article

Correlation of lung function and respiratory muscle strength with functional exercise capacity in obese individuals with obstructive sleep apnea syndrome

Associação entre função pulmonar, força muscular respiratória e capacidade funcional de exercício em indivíduos obesos com síndrome da apneia obstrutiva do sono

Thays Maria da Conceição Silva Carvalho1,a, Anísio Francisco Soares2,b, Danielle Cristina Silva Climaco3,c, Isaac Vieira Secundo3,d, Anna Myrna Jaguaribe de Lima2,e

J Bras Pneumol.2018;44(4):279-284

Applicability of the 12-Item Short-Form Health Survey in patients with progressive systemic sclerosis

Aplicabilidade do questionário de qualidade de vida relacionada à saúde - the 12-Item Short-Form Health Survey - em pacientes portadores de esclerose sistêmica progressiva

Thamine Lessa Andrade, Aquiles Assunção Camelier, Fernanda Warken Rosa, Marcia Pina Santos, Sérgio Jezler, Jorge Luiz Pereira e Silva

J Bras Pneumol.2007;33(4):414-422

Images in Pulmonary Medicine

Bubbles in my heart—systemic air embolism after CT-guided transthoracic biopsy of a pulmonary nodule

Felipe Marques da Costa1, Augusto Kreling Medeiros2, Felipe Roth Vargas3

J Bras Pneumol.2024;50(5):e20240227

Case Report

Alveolar hemorrhage associated with lupus nephritis

Hemorragia alveolar associada a nefrite lúpica

Ricardo Henrique de Oliveira Braga Teixeira, Marcel Hiratsuka, Flávia Calderini Rosa, Rogério Souza, Carlos Roberto Ribeiro de Carvalho

J Bras Pneumol.2003;29(6):401-404

Editorial

Acute lung injury and acute respiratory distress syndrome: diagnostic hurdles

Lesão pulmonar aguda e síndrome do desconforto respiratório agudo: dificuldades diagnósticas

Carmen Sílvia Valente Barbas

J Bras Pneumol.2007;33(4):25-26

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