Original Article

Immunohistochemical study of lung remodeling in mice exposed to cigarette smoke

Estudo imunohistoquímico do remodelamento pulmonar em camundongos expostos à fumaça de cigarro

Samuel Santos Valença, Luís Cristóvão Porto

J Bras Pneumol.2008;34(10):787-795

Oxidative damage induced by cigarette smoke exposure in mice: impact on lung tissue and dia-phragm muscle

Dano oxidativo induzido por exposição a fumaça de cigarro em camundongos: impacto sobre o pulmão e o músculo diafragma

Samanta Portão de Carlos, Alexandre Simões Dias, Luiz Alberto Forgiarini Júnior, Patrícia Damiani Patricio, Thaise Graciano, Renata Tiscoski Nesi, Samuel Valença, Adriana Meira Guntzel Chiappa, Gerson Cipriano Jr, Claudio Teodoro de Souza, Gaspar Rogério da Silva Chiappa

J Bras Pneumol.2014;40(4):411-420

Effects of passive inhalation of cigarette smoke on structural and functional parameters in the respiratory system of guinea pigs

Efeitos da inalação passiva da fumaça de cigarro em parâmetros estruturais e funcionais no sistema respiratório de cobaias

Thiago Brasileiro de Vasconcelos1, Fernanda Yvelize Ramos de Araújo1, João Paulo Melo de Pinho2, Pedro Marcos Gomes Soares1, Vasco Pinheiro Diógenes Bastos3

J Bras Pneumol.2016;42(5):333-340

Sociodemographic and clinical characteristics of individuals exposed to smoking or biomass smoke and followed at primary health care centers in Brazil: a multicenter study

Juliana O Barros1, Flavio F Arbex2, Alcindo Cerci Neto3, Leandro G Fritscher4, Suzana E Tanni5, Gerson F Souza6, Oliver A Nascimento1,7, José R Jardim1

J Bras Pneumol.2025;51(3):e20250001

Objective: To describe the sociodemographic and clinical characteristics of individuals exposed to smoking or biomass smoke and followed at primary health care (PHC) centers across three states in Brazil. Methods: This was a cross-sectional multicenter study including patients followed at any of four PHC centers in Brazil. Patients = 35 years of age who were smokers or former smokers, or were exposed to biomass smoke were included, the exception being those with physical/mental disabilities and those who were pregnant. Face-to-face assessments included a questionnaire assessing clinical and sociodemographic characteristics, as well as the COPD Assessment Test (CAT) and the modified Medical Research Council (mMRC) dyspnea scale. Results: Of a total of 737 patients, 56.3% were female and 64.2% were White, with a mean age of 57.7 ± 11.8 years. Most (54.4%) had < 9 years of schooling, 50.2% had low socioeconomic status, and 71.5% were overweight/obese. Smokers accounted for 43.4% of the study sample, whereas 15.0% had no direct exposure to cigarette smoke. Common symptoms included cough, in 37.3%; wheezing, in 33.8%; and phlegm, in 27.4%. Most (75.1%) of the study participants had mMRC dyspnea scale scores of 0 or 1. CAT scores were 0-10, in 40.2%; 11-20, in 44.6%; 21-30, in 14.1%; and 31-40, in 1.1%. Binary logistic regression showed that sex and age significantly impacted mMRC dyspnea scale predictions, whereas BMI and socioeconomic status influenced CAT predictions. Common comorbidities included hypertension, in 51.3%; depression, in 27.4%; and diabetes, in 24.3%. No association was found between hypertension and obesity or smoking, or between diabetes and obesity or smoking. Conclusions: PHC patients with risk factors such as smoking and exposure to biomass smoke have a high comorbidity burden, with over half experiencing mild to moderate quality-of-life impacts. This study emphasizes the need for targeted preventive measures in PHC settings.

Keywords: Smoking; Risk factors; Biomass; Primary health care.

Editorial

A murine model of elastase- and cigarette smoke-induced emphysema: is it an opportunity to understand CT emphysema in humans?

Modelo murino de enfisema induzido por elastase e fumaça de cigarro: uma oportunidade para entender o enfisema na TC em seres humanos?

Alfredo Nicodemos Cruz Santana1

J Bras Pneumol.2017;43(2):83-84

Case Report

Lung cancer in workers exposed to silica

Câncer de pulmão em trabalhadores expostos à sílica

Ana Paula Scalia Carneiro, Max Anderson Morales dos Santos, Plínio Vasconcelos Maia, Sandhi Maria Barreto

J Bras Pneumol.2002;28(4):233-236

Original Article

Comparative study of respiratory symptoms and lung function alterations in patients with chronic obstructive pulmonary disease related to the exposure to wood and tobacco smoke

Estudo comparativo de sintomas respiratórios e função pulmonar em pacientes com doença pulmonar obstrutiva crônica relacionada à exposição à fumaça de lenha e de tabaco

Maria Auxiliadora Carmo Moreira, Maria Rosedália de Moraes, Daniela Graner Schwartz Tannus Silva, Thayssa Faria Pinheiro, Huber Martins Vasconcelos Júnior, Lanucy Freita de Lima Maia, Daine Vargas do Couto

J Bras Pneumol.2008;34(9):661-666

A new experimental model of cigarette smoke-induced emphysema in Wistar rats

Um novo modelo experimental de enfisema induzido por fumaça de cigarro em ratos Wistar

Rodrigo de las Heras Kozma, Edson Marcelino Alves, Valter Abraão Barbosa-de-Oliveira, Fernanda Degobbi Tenorio Quirino dos Santos Lopes, Renan Cenize Guardia, Henrique Vivi Buzo, Carolina Arruda de Faria, Camila Yamashita, Manzelio Cavazzana Júnior, Fernando Frei, Maria José de Oliveira Ribeiro-Paes, João Tadeu Ribeiro-Paes

J Bras Pneumol.2014;40(1):46-54

Acute lung injury induced by the intravenous administration of cigarette smoke extract

Lesão pulmonar aguda induzida pela administração endovenosa de extrato da fumaça do cigarro

Luciana Gomes Menezes, Juliana Alves Uzuelli, Cristiane Tefé-Silva, Simone Gusmão Ramos, José Eduardo Tanus dos Santos, José Antônio Baddini Martinez

J Bras Pneumol.2013;39(1):39-47

A murine model of elastase- and cigarette smoke-induced emphysema

Modelo murino de enfisema induzido por instilação de elastase e exposição a fumaça de cigarro

Rubia Rodrigues1, Clarice Rosa Olivo1, Juliana Dias Lourenço1, Alyne Riane1, Daniela Aparecida de Brito Cervilha1, Juliana Tiyaki Ito1, Milton de Arruda Martins1, Fernanda Degobbi Tenório Quirino dos Santos Lopes1

J Bras Pneumol.2017;43(2):95-100

Immunohistochemical and morphometric evaluation of COX‑1 and COX-2 in the remodeled lung in idiopathic pulmonary fibrosis and systemic sclerosis

Avaliação imuno-histoquímica e morfométrica de COX-1 e COX-2 no remodelamento pulmonar na fibrose pulmonar idiopática e na esclerose sistêmica

J Bras Pneumol.2013;39(6):692-700

Prevalence of smoking and reasons for continuing to smoke: a population-based study

Prevalência de tabagismo e motivos para continuar a fumar: estudo de base populacional

Simone Aparecida Vieira Rocha1,a, Andréa Thives de Carvalho Hoepers1,b, Tânia Silvia Fröde2,c, Leila John Marques Steidle3,d, Emilio Pizzichini3,e, Márcia Margaret Menezes Pizzichini3,f

J Bras Pneumol.2019;45(4):e20170080

Uncoupling protein-2 mRNA expression in mice subjected to intermittent hypoxia

Expressão do mRNA da uncoupling protein-2 em camundongos submetidos à hipóxia intermitente

Luciana Rodrigues Vieira, Denis Martinez, Luiz Felipe Forgiarini, Darlan Pase da Rosa, Gustavo Alfredo Ochs de Muñoz, Micheli Fagundes, Emerson Ferreira Martins, Carolina Caruccio Montanari, Cintia Zappe Fiori

J Bras Pneumol.2015;41(2):167-174

Review Article

Lung tissue remodeling in the acute respiratory distress syndrome

Remodelamento do tecido pulmonar na síndrome do desconforto respiratório agudo

Alba Barros de Souza, Flavia Brandão dos Santos, Elnara Marcia Negri, Walter Araujo Zin, Patricia Rieken Macedo Rocco

J Bras Pneumol.2003;29(4):235-245

Original Article

Profile of 300 workers exposed to silica seen in an university outpatient clinic

Perfil de 300 trabalhadores expostos à sílica atendidos ambulatorialmente em Belo Horizonte

Ana Paula Scalia Carneiro, Luciano de Oliveira Campos, Marcelo Fonseca Coutinho Fernandes Gomes, Ada Ávila Assunção

J Bras Pneumol.2002;28(6):329-334

Review Article

Bronchial remodeling in asthma

Remodelamento brônquico na asma

Thais Mauad, Alessandra Sandrini Lopes de Souza, Paulo Hilário Nascimento Saldiva, Marisa Dolhnikoff4

J Bras Pneumol.2000;26(2):91-98

Impact of exposure to smoke from biomass burning in the Amazon rain forest on human health

Impacto da exposição à fumaça da queima de biomassa na Floresta Amazônica na saúde humana

Marilyn Urrutia-Pereira1,2,3, Luciana Varanda Rizzo4, Herberto José Chong-Neto5,6,7,8, Dirceu Solé3,9,10,11

J Bras Pneumol.2021;47(5):e20210219

Original Article

Immunoglobulins, complements and autoantibodies in 58 workers exposed to silica

Estudo de imunoglobulinas, complementos e auto-anticorpos em 58 trabalhadores expostos à sílica

Hermano Albuquerque de Castro, Carolina Gimenes da Silva, Alfred Lemle

J Bras Pneumol.2004;30(3):201-206

Letters to the Editor

Talc asbestosis and pulmonary tuberculosis in a patient exposed to the talc used in the production of soccer balls

Talcoasbestose e tuberculose pulmonar em paciente exposta a talco em confecção de bolas de futebol

Olívia Meira Dias, Mauro Canzian, Mário Terra-Filho, Ubiratan de Paula Santos

J Bras Pneumol.2011;37(4):563-566

Original Article

Genetic polymorphisms and their effects on the severity of silicosis in workers exposed to silica in Brazil

Polimorfismos genéticos e seus efeitos na gravidade da silicose em trabalhadores expostos à sílica no Brasil

Marcos César Santos de Castro1,2,3, Angela Santos Ferreira Nani2, Kaio Cezar Rodrigues Salum1, Jônatas de Mendonça Rolando1, Júlia Fernandes Barbosa dos Santos1, Hermano Albuquerque de Castro4, Patrícia Canto Ribeiro4, Walter Costa3, Cícero Brasileiro de Mello1,5, Fabiana Barzotto Kohlrausch5

J Bras Pneumol.2022;48(5):e20220167

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